Image Description
Microscopically, Peutz-Jeghers polyps show a complex glandular architecture lined by normal appearing epithelium. The lamina propria shows arborizing network of smooth muscle fascicles that are contiguous with muscularis mucosa. The smooth muscle becomes progressively thinner as it reaches the polyp surface. Besides the columnar epithelium and goblet cells, other cell types such as Paneth cells may also be present. There is no atypia.
About the Disease
Hamartomatous polyps of gastrointestinal tract occur sporadically as well as components of genetic or acquired syndromes. When occurring in the syndromic setting, some of them are associated with germline mutations in tumor suppressor genes or oncogenes and carry increased risk of malignancies. Juvenile polyps and polyps associated with Peutz-Jeghers Syndrome will be addressed in this section. References: 1. Feldman, M., Friedman, L. S., & Brandt, L. J. (2016). Sleisenger & Fordtrans Gastrointestinal & Liver Disease; 10th Edition. Philadelphia, PA. Elsevier Saunders. 2. Goldblum, J. R. et al (2018). Rosai and Ackermans Surgical Pathology; Eleventh Edition. Philadelphia, PA. Elsevier. 3. Kumar, V., Abbas, A. K., & Aster, J. C. (2015). Robbins and Cotran Pathologic Basis of Disease; Ninth Edition. Philadelphia, PA. Elsevier.