Image Description
Microscopically, the surface of a juvenile polyp shows ulceration and granulation tissue along with regenerating epithelium which may be mistaken for dysplasia. The cystic spaces are formed by dilated glands containing abundant mucin and inflammatory debris. The glands are separated by an expanded edematous lamina propria containing inflammatory cells.
About the Disease
Hamartomatous polyps of gastrointestinal tract occur sporadically as well as components of genetic or acquired syndromes. When occurring in the syndromic setting, some of them are associated with germline mutations in tumor suppressor genes or oncogenes and carry increased risk of malignancies. Juvenile polyps and polyps associated with Peutz-Jeghers Syndrome will be addressed in this section. References: 1. Feldman, M., Friedman, L. S., & Brandt, L. J. (2016). Sleisenger & Fordtrans Gastrointestinal & Liver Disease; 10th Edition. Philadelphia, PA. Elsevier Saunders. 2. Goldblum, J. R. et al (2018). Rosai and Ackermans Surgical Pathology; Eleventh Edition. Philadelphia, PA. Elsevier. 3. Kumar, V., Abbas, A. K., & Aster, J. C. (2015). Robbins and Cotran Pathologic Basis of Disease; Ninth Edition. Philadelphia, PA. Elsevier.