Image Description
About 15% of colorectal carcinomas (CRCs), including Hereditary Non-polyposis Colorectal Cancer (HNPCC; Lynch Syndrome), right-sided sporadic CRC, and serrated adenocarcinomas show defective DNA mismatch repair (MMR) pathway leading to microsatellite instability (MSI).
These tumors show hypermutations, are more likely to be poorly-differentiated with little or no gland formation or show mucinous differentiation. Growth pattern is often circumscribed. Tumor infiltrating lymphocytes are consistently present.
These tumors show hypermutations, are more likely to be poorly-differentiated with little or no gland formation or show mucinous differentiation. Growth pattern is often circumscribed. Tumor infiltrating lymphocytes are consistently present.