AdenoCA of Colon : Signet Ring Cell

Signet ring cell carcinoma of colon showing classic histologic pattern. The tumor cells are arranged singly, in clusters, and anastomosing cords. The intracellular mucin blob pushes the nucleus to one side, flattening it against the cytoplasmic membrane, and creates a signet ring appearance. This case shows both intracellular mucin as well as extracellular mucin lakes.