Image Description
Pushing expansive margins with smooth rounded contours are associated with MSI-high phenotype and pursue a less aggressive clinical course. Tumors with irregular, jagged infiltrative margins (as shown in this image) are aggressive.
Tumor budding, defined as a cluster of 5 or less tumor cells infiltrating into the desmoplastic stroma at the advancing tumor edge is a recently described adverse prognostic factor.
Tumor budding, defined as a cluster of 5 or less tumor cells infiltrating into the desmoplastic stroma at the advancing tumor edge is a recently described adverse prognostic factor.