Gallbladder ICPN : Clinical Features

Clinical Features: Intracholecystic papillary-tubular neoplasms (ICPN) of gallbladder occur in older adults (mean age at diagnosis 61 years) and are more common in females. The tumors may be clinically silent and found incidentally (50%) or present with right upper quadrant abdominal pain (50%). There is no known association with gallstones, although they may coexist in some cases (as shown here). Rare cases are associated with Peutz-Jeghers syndrome, Gardner syndrome, anomalous union of pancreatobiliary ducts, or Brunner gland hamartoma of the duodenum. On imaging studies, they are often designated as gallbladder cancer.

The image shows an ICPN discovered incidentally as a 2.5 cm, multinodular sessile mass (left edge) in an adult female who underwent laparoscopic cholecystectomy for gallstones.