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Acute Calculous Cholecystitis - Macroscopic Features: The gallbladder usually shows external signs of inflammation, such as enlargement with edema of the wall, omental adhesions, and pericholecystic fluid. The serosa is dull and may be covered with patchy fibrinopurulent exudate. The serosal surface may be congested, hemorrhagic, or frankly gangrenous with deep red, purple, or black discoloration. The lumen contains one or more gallstones (as seen in this image).

Image courtesy of: Dr. Ibrahim Zardawi; used with permission.
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