PanNET : Prognosis
Image Description
Prognosis of Non-functioning Pancreatic Neuroendocrine Tumors (NF-PanNETs): The cure rate for NF-PanNETs is low. Between 55%-75% of cases behave aggressively, with extrapancreatic extension, distant metastases, or recurrences. Following surgical resection, the overall 5-yr survival rate is 65%-86% and the 10-yr survival rate is 45%-68%. The 5-yr survival for Grade 2 and Grade 3 PanNETs is 62% and 29% respectively. Pancreatic neuroendocrine microadenomas (tumors <0.5 cm) are considered benign with 100% survival.
The median survival time even after metastases or recurrence is several years. Since metastases can occur many years after resection of the primary tumor, long-term follow-up is necessary.
The most important prognostic factor in PanNETs is the proliferative rate as assessed by the mitotic count and Ki-67 labeling index. Tumor size also correlates with outcome. Tumors < 2.0 cm are indolent, where as tumors > 3.0 cm have a high risk of metastasis. . Patients with DAXX or ATRX mutations have a worse clinical outcome than those without these mutations.
The specific hormone/s produced by the PanNETs as well as the individual histologic patterns have no clinical or prognostic significance.
About this image: PanNet composed of nests of uniform tumor cells separated by delicate fibrovascular stroma.
The median survival time even after metastases or recurrence is several years. Since metastases can occur many years after resection of the primary tumor, long-term follow-up is necessary.
The most important prognostic factor in PanNETs is the proliferative rate as assessed by the mitotic count and Ki-67 labeling index. Tumor size also correlates with outcome. Tumors < 2.0 cm are indolent, where as tumors > 3.0 cm have a high risk of metastasis. . Patients with DAXX or ATRX mutations have a worse clinical outcome than those without these mutations.
The specific hormone/s produced by the PanNETs as well as the individual histologic patterns have no clinical or prognostic significance.
About this image: PanNet composed of nests of uniform tumor cells separated by delicate fibrovascular stroma.