Prognostic Factors : MYCN Amplification

Amplification of MYCN oncogene on chromosome 2p24 is seen in about 25% of neuroblastomas and predicts poor prognosis. Patients with MYCN amplification show rapid tumor progression and decreased survival as depicted in this graph. Image modified from: Copy number gain of MYCN gene is a recurrent genetic aberration in Chinese pediatric neuroblastoma patients Authors: Miao Wang, Chunju Zhou, Rongqin Cai, Yong Li and Liping Gong. Diagnostic Pathology 2013, 8:5; Used in accordance with Creative Commons License 2.0