Neuroblastoma : Diagnosis
Image Description
According to internationally accepted criteria, the diagnosis of neuroblastoma must be based on one of the following: 1) An unequivocal pathologic diagnosis made from the tumor tissue by light microscopy (with or without ancillary studies, including immunohistochemistry, electron microscopy, increased levels of serum catecholamines or urinary catecholamine metabolites (VMA, HVA). 2) The combination of a bone marrow aspirate or a trephine biopsy containing unequivocal tumor cells and increased levels of serum catecholamines or urinary catecholamine metabolites. This undifferentiated neuroblastoma is a higher magnification of the previous image.