Image Description
The intermixed subtype of ganglioneuroblastoma shows all stages of neuronal differentiation throughout the tumor. The differentiating neuroblasts have moderate to abundant acidophilic or amphophilic cytoplasm and an enlarged eccentric vesicular nucleus with a single prominent nucleolus. The ganglion cells may be immature, multinucleated, or morphologically abnormal. The background consists of a fine, fibrillary network (neuropil) composed of abundant neurites arising from the differentiating ganglion cells. There is a histologic overlap between differentiating neuroblastoma and ganglioneuroblastoma.