Fat Necrosis : Breast

Fat necrosis in breast may result from surgery, radiation, or incidental trauma. Clinically, it may produce a superficial painless mass with skin retraction that may be difficult to distinguish from recurrent carcinoma in patients who have undergone surgery and radiation therapy. Sections show disruption of fat, lipid-laden macrophages, chronic inflammation and foreign body giant cell reaction. Hemosiderin deposition may also be seen.