Intraductal Papilloma of Breast : Apocrine change

This image shows apocrine metaplasia in an intraductal papilloma. The main differential diagnosis is intraductal papillary carcinoma. Features favoring papilloma include: well-developed stroma in papillary folds, two cell types, lack of cytologic atypia, presence of apocrine metaplasia, and lack of cribriform or trabecular patterns.