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Urothelial Carcinoma-in-situ

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UrinaryBladder_FlatLesions_CIS2.jpg

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The urothelial lining consists of large atypical hyperchromatic cells with considerable variation in nuclear size and shape. The complete loss of polarity is obvious here. There is overcrowding and the cells appear piled up on top of one another. The lamina propria is hypervascular and contain scattered chronic inflammatory cells.

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