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Crohn Disease : Microscopic

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Microscopic Features of Crohn Disease: There is considerable overlap in histologic features between Crohn disease and ulcerative colitis. Deep ulcers (clearly seen in this colectomy specimen) and fissures, transmural inflammation, and epithelioid granulomas are diagnostic hallmarks of Crohn disease.

In endoscopic biopsies, the helpful diagnostic features of Crohn disease are patchy mucosal inflammation, granulomas, preservation of goblet cells, pyloric gland metaplasia, and relative preservation of crypt architecture. Image courtesy of Dr. Jean-Christophe Fournet, Paris, France; humpath.com; Used with permission

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