Desmoplastic Small Round Cell Tumor : NSE
Comments:
Desmoplastic small round cell tumors (DSRCT) are characterized by co-expression of epithelial, mesenchymal, and neural markers. POSITIVE: Majority of the cases are positive for cytokeratin AE1/AE3, EMA, vimentin, desmin (paranuclear dot-like positivity), WT1 (antibody to carboxy terminus; nuclear expression) and NSE (shown here). NEGATIVE: The tumor cells are negative for CK20, CK5/6, MyoD1, and myogenin. OCCASIONALLY POSITIVE: The markers that are sometimes positive include: CD99, synaptophysin, chromogranin, neurofilament, S-100 protein, and CA-125. Image courtesy of Dr. Jean-Christophe Fournet, Paris, France; humpath.com; Used with permission