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Reed-Sternberg Cells : CD45

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Reed-Sternberg cells and variants are negative for CD45. This feature is useful in differentiating classic Hodgkin lymphoma (cHL) from nodular lymphocyte-predominant Hodgkin lymphoma (LP cells positive for CD45) and various non-Hodgkin lymphomas which may mimic cHL.

This image from nodular sclerosis cHL shows a cluster of lacunar cells which are negative for CD45.

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