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Partial Hydatidiform Mole

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Case History: A 30 y/o female with 14 weeks' history of amenorrhea presented with intermittent vaginal bleeding as well as passage of clots with tissue fragments. Clinical examination revealed small for date uterus. Ultrasonography revealed abnormal placenta with multifocal sonolucencies and a live fetus. She underwent medical termination of pregnancy. The photograph shows placental tissue with admixture of grossly vesicular and normal villi and blood clots. Also seen is a fetus with umbilical cord around the neck.

A partial mole occurs when a haploid egg is fertilized by two sperm or by one sperm which reduplicates itself yielding the genotypes of 69, XXY (triploid) or 92, XXXY (tetraploid). Incomplete moles can become invasive (<5% risk) but are not associated with choriocarcinoma. In contrast, complete hydatidiform moles have 2.5% risk of developing into choriocarcinoma and a 10% risk of becoming an invasive mole.

Case courtesy of: Dr. Sanjay D. Deshmukh, Professor of Pathology, Dr. Vithalrao Vikhe Patil Medical College & Hospitals, Ahmednagar, India.

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