Large B-cell Lymphomas in AITL
B-cell lymphoproliferation in Angioimmunoblastic T-cell Lymphoma (AITL): Large B-cell lymphomas can arise in a background of AITL. They may be present at initial diagnosis or develop subsequently. Most of them are EBV-driven lymphoproliferative disorders. Morphologically, they are characterized by the presence of large blast-like cells in a background of typical AITL. They can resemble immunoblasts, centroblasts, or Hodgkin cells. They may be present as single scattered cells, small clusters, or large sheets which are indistinguishable from diffuse large B-cell lymphoma. Immunophenotypically, they are positive for EBV-encoded small RNA, CD20, and CD30 and negative for CD15.