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Adamantinomatous Craniopharyngioma

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Higher magnification of a nodule of wet keratin composed of anucleated squames (ghost cells). The optimal treatment of craniopharyngioma is controversial. Given the location of the tumor (sellar/suprasellar region), complete resection is technically challenging and risks damaging optic chiasm and the hypothalamo-pituitary axis. Other approaches include subtotal resection with observation, cyst aspiration, intracystic administration of bleomycin, and radiation therapy. Five-year survival rates are excellent; however, many patients require lifelong pituitary hormone replacement.

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