Follicular Dendritic Cell Networks in AITL : CD23
Follicular Dendritic Cell (FDC) Networks in Angioimmunoblastic T-cell Lymphoma (AITL): Proliferation of follicular dendritic cells outside residual follicles is a characteristic feature of AITL. The FDC abut the high endothelial venules - another key histologic feature of AITL. In some cases, the "burned-out" follicles are surrounded by concentric layers of FDC creating an "onion-skin appearance." In subtle cases, FDC networks can be highlighted by immunostains for CD21, CD23, or CD35.