T-cell/Histiocyte-rich Large B-cell Lymphoma : Clinical Features

Comments:
Clinical Features: T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) usually affects patients in 6th or 7th decades of life with a slight male predominance (M:F=1.7:1). However, some cases have been reported in children.

It is primarily a nodal disease, although extranodal sites are frequently involved, including bone marrow (60% of cases) and spleen (25% of cases). Patient present with fever, malaise, splenomegaly, and/or hepatomegaly. As compared to diffuse large B-cell lymphoma, NOS, it is more aggressive and likely to present in stage III or IV.

The image shows scattered large atypical lymphoid cells (B-cells) in a background of abundant small lymphocytes (T-cells).