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T-cell/Histiocyte-rich Large B-cell Lymphoma : CD3

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Immunophenotype of T-cell/histiocyte-rich large B-cell lymphoma:

Neoplastic large cells: They express pan B-cell markers (CD20, CD22, CD79a, & PAX5) and show variable light chain restriction. CD15, CD30, CD5, and CD10 are usually negative. They express BCL2 (40% of cases) and BCL6 (40% to 60% of cases). EMA is positive in about 30% of cases. EBV is negative.

Background cells: The small lymphocytes that make up the bulk of the lesion are reactive T-cells of cytotoxic type that express CD3 (shown here), CD8, and TIA-1. There are variable numbers of CD68+ and CD163+ histiocytes. Small reactive B-cells are rare.

The neoplastic large B-cells should not be surrounded by rosettes of follicular T-cells (CD57+, PD-1+) or meshwork of CD21-positive follicular dendritic cells. These features are seen in nodular lymphocyte-predominant Hodgkin lymphoma.

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