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DLBCL : Spleen

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Diffuse large B-cell lymphoma is the most common primary splenic lymphoma. It may present as small discrete or large coalescing nodules that frequently extend into contiguous structures. Most are Bcl-6 positive. This example was composed predominantly of immunoblasts. Note the single prominent centrally located nucleolus in the tumor cells. A few non-neoplastic reactive lymphocytes are scattered in the background. These are CD3+ T-cells.

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