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DLBCL : Gene Expression

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Gene expression profiling using DNA microarrays have identified 2 groups of diffuse large B-cell lymphomas: 1) germinal center B-cell like (GCB) - that expresses genes characteristic of germinal center B-cells and correlates with the presence of BCL2 rearrangement and t(14;18) translocation; 2) activated B-cell like (ABC) - which correlates with BCL6 rearrangement and t(3;14)(q27;q32). Of the two types, GCB has better prognosis than the ABC type with current chemotherapeutic regimens.

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