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Neuroblastoma : Clinical Features - II

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In some cases of neuroblastoma, catecholamine release may give rise to symptoms similar to those seen in Pheochromocytoma paroxysmal hypertension, palpitations, flushing, and headache. Cervical tumors near stellate ganglion may present with Horner syndrome (ptosis, miosis, enophthalmos). Rare patients develop paraneoplastic neurologic manifestations, including opsoclonus-myoclonus-ataxia syndrome. It believed to have an auto-immune basis and is associated with neurologic and cognitive deficits which may improve only partially following the removal of the tumor. Ironically, the patients who present with opsoclonus-myoclonus syndrome often have neuroblastomas with favorable biological features. The image shows a well-circumscribed tumor arising in the adrenal medulla. The remnant of adrenal cortex can be seen on the top in the left half of the image. The cut-surface is pink-tan with abundant coarse and punctate calcifications (yellow-white specks). Image courtesy of Dr. Jean-Christophe Fournet, Paris, France; humpath.com; Used with permission

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