Myeloma Kidney : Morphology

Comments:
In up to 25% of myeloma patients, the renal damage is mediated by the development of amyloidosis of AL type due to deposition of free light chains (lambda type) in the interstitium. In some patients, there is deposition of kappa light chains in the glomerular basement membranes, mesangial matrix (shown here), as well as in the tubular basement membrane.

Image courtesy of: Dr. Ibrahim Zardawi; used with permission.