Insulinoma : Molecular Genetics
Molecular Pathogenesis of Insulinomas: Sporadic solitary insulinomas are of unknown origin. Patients with germline mutations in MEN1 gene develop insulinomas among other PanNET. Insulinomas arising in the setting of familial insulinomatosis are associated with germline mutations in MAFA gene. Additional comments on the molecular pathogenesis of insulinomas are under non-functioning pancreatic neuroendocrine tumors. The image shows insulinoma composed of anastomosing trabeculae on the right and normal pancreas on the upper left.