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Gliomatosis peritonei : Clinical

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CLINICAL FEATURES: Patients with gliomatosis peritonei (GP) usually present with acute abdominal pain and distension. The peak incidence is in the second decade. At laparotomy, the surgeon finds peritoneum and omentum are studded with miliary, firm, greyish white nodules, measuring up to 3 mm in size. GP is diagnosed at the same time as the primary ovarian neoplasm in the majority of cases (71%). About 50% of patients have metastases at the time of diagnosis (immature teratoma, mature teratoma, or both). The pathogenesis is not exactly understood. A widely favored hypothesis is that mature glial tissue leaks through a defect in the capsule of the primary tumor, which is usually an immature teratoma.

Reference: Liang L et al. Gliomatosis peritonei: a clinicopathologic and immunohistochemical study of 21 cases. Modern Pathology (2015) 28:1613-1620.

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