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MPNST : Cytologic Features

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Malignant peripheral nerve sheath tumor (MPNST) is a highly cellular neoplasm resembling fibrosarcoma and is composed of monomorphic spindle cells arranged in interlacing fascicles, palisades, and whorls. The cells have comma-shaped, wavy or buckled hyperchromatic nuclei (as seen here) and indistinct pale or eosinophilic cytoplasm. Some cases have plump oval or rounded nuclei.

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