Lipoma : Role of HMGA2

Comments:
Role of HMGA2: HMGA family of proteins (HMGA1a, HMGA1b, HMGA1c, and HMGA2) regulate gene expression by binding to AT-rich regions in the minor groove of DNA. HMGA2 is highly expressed in embryonic stem cells during embryogenesis and plays a key role in the normal development of mesodermal tissues. Its expression is more limited during later stages of development and in adulthood. HMGA2 is dysregulated and re-expressed in nearly all human cancers.

Image source: Mansoori B, Mohammadi A, Ditzel HJ, Duijf PHG, Khaze V, Gjerstorff MF, Baradaran B. HMGA2 as a Critical Regulator in Cancer Development. Genes. 2021; 12(2):269. https://doi.org/10.3390/genes12020269; used under Creative Commons Attribution (CC BY) license.