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Anaplastic Large Cell Lymphoma

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The tumor cells are positive for CD30 in a membranous and paranuclear Golgi-type dot pattern. Majority of the systemic cases (70% to 80%) carry t(2;5)(p23;q35) translocation resulting in the formation of NPN-ALK chimeric protein that can be detected by immunohistochemistry. Additional findings are T-cell receptor gene rearrangements and expression of pan-lymphoid and some T-cell related markers. B-cell markers are negative.

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