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Gaucher Disease

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The most common type, Type I (non-neuronopathic form) results in accumulation of lipids in spleen and skeletal systems. Type II (Acute neuronopathic form) shows CNS involvement with early death. Type III has features intermediate between types I and II. The fibrillary appearance of the cytoplasm of Gaucher cells likened to crumpled tissue paper can be seen here.

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