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Mammary Paget Disease : Introduction

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Introduction: Paget disease (PD) of the nipple and areola is a form of intraepidermal adenocarcinoma that is almost always associated with in-situ or invasive breast cancer (82% to 94% of cases). It is rare, accounting for 1% to 3% of all breast cancers.

It is characterized by an eczematous, scaling, pruritic eruption of the skin that closely mimics inflammatory dermatoses of the nipple/areola, often delaying the diagnosis.

PD has been observed in ectopic breast tissue, supernumerary nipples, and in the male breast. The underlying carcinoma is multicentric in 32% to 41% of cases. Invasive breast carcinoma associated with PD tends to be more aggressive and often shows high grade, positive lymph nodes, negativity for ER/PR, and strong positivity for HER2.

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