Ductal Carcinoma-in-situ : Comedonecrosis
In DCIS with comedonecrosis, the involved duct shows a solid growth with high nuclear grade along the perimeter of the duct. Mitotic activity is brisk and necrosis is always present in the lumen. Coarse calcifications may be present in the necrosis. The periductal tissue shows fibrosis and evidence of angiogenesis.