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Heterotopic Pancreas : Clinical

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Pancreas_Heterotopia12_Stomach.jpg

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Clinical Features: Pancreatic heterotopia is a congenital lesion; however, most symptomatic cases are diagnosed in adulthood (average age 45 years). About 50-75% of patients have no symptoms.

Patients can develop abdominal discomfort or pain, nausea, vomiting, and gastrointestinal bleeding. Large lesions in the prepyloric region can cause gastric outlet obstruction. Intussusception has resulted in some cases. The heterotopic tissue can also develop lesions typical of pancreas, including pancreatitis, cysts, neuroendocrine tumors, or ductal adenocarcinoma.

About this image: This is an example of incidentally identified heterotopic pancreas in stomach, treated by wedge resection. The clinical impression was gastrointestinal stromal tumor or neuroendocrine tumor. Note the overlying smooth gastric mucosa. See cut surface in the next image.

Image courtesy of: Dr. Farid Azmoudeh-Ardalan, Professor of Pathology, Tehran University of Medical Sciences, Tehran, Iran; used with permission

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