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Juvenile Polyposis Syndrome

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Juvenile polyposis syndrome is an autosomal dominant condition in which the colon is studded with a large number of polyps. This may require colectomy due to severe hemorrhage resulting from polyp ulceration. Patients may also harbor polyps in stomach and small intestine that carry a risk of malignant transformation. The extraintestinal manifestations of juvenile polyposis syndrome include digital clubbing, pulmonary arteriovenous malformation and other congenital malformations.

This image from a juvenile polyposis syndrome patient shows a cystically dilated gland with mucin and inflammatory debris.

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