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AdenoCA of Colon : Signet Ring Cell

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Signet ring cell carcinoma of colon showing classic histologic pattern. The intracellular mucin blob pushes the nucleus to one side, flattening it against the cytoplasmic membrane, and creates a signet ring appearance. Some cases contain both intracellular mucin blob as well as extracellular mucin lakes (as seen in this case).

Primary signet ring cell carcinoma of colon is rare and makes up about 1% of all colorectal carcinomas. Metastases from sites such as breast, ovary and stomach should be excluded.

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