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AdenoCA of Colon : Tumor Margins

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Pushing expansive margins with smooth rounded contours are associated with MSI-high phenotype and pursue a less aggressive clinical course. Tumors with irregular, jagged infiltrative margins (as shown in this image) are aggressive.

Tumor budding, defined as a cluster of 5 or less tumor cells infiltrating into the desmoplastic stroma at the advancing tumor edge is a recently described adverse prognostic factor.

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