Crohn Disease : Microscopic
Microscopic Features of Crohn Disease: There is considerable overlap in histologic features between Crohn disease and ulcerative colitis. Deep ulcers and fissures, transmural inflammation, and epithelioid granulomas are diagnostic hallmarks of Crohn disease. This is a colectomy specimen from a patient with Crohn disease. A small focus of uninvolved mucosa in the center is surrounded by ulcers on either side. There is transmural inflammation and numerous lymphoid aggregates and granulomas.