Papillary Craniopharyngioma

Papillary subtype makes up approximately 10% of all craniopharyngiomas and is almost always seen in adults. The usual location is suprasellar or intraventricular. Due to their proximity to hypothalamic structures and pituitary, the presentation is usually with visual disturbances, personality changes, and hormonal imbalances. Papillary craniopharyngiomas more often tend to be solid and rarely show calcification (unlike adamantinomatous variant). They are composed of sheets of well-differentiated non-keratinizing squamous epithelium (WHO Grade 1). Dehiscence of epithelium around fibrovascular cores often results in pseudopapillary architecture as seen here.