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Urothelial Carcinoma-in-situ

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Some cases of urothelial carcinoma-in-situ show neoplastic cells that are somewhat monomorphic as seen here. The cells have abundant eosinophilic cytoplasm and conspicuously lack significant pleomorphism; however, the nuclei are enlarged and show one or more prominent nucleoli. Mitotic features are readily seen. The normal orientation of cells on the basement membrane (polarity) also appears to be altered.

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