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Respiratory Epithelial Adenomatoid Hamartoma

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Nasopharynx_REAH1.jpg

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Respiratory epithelial adenomatoid hamartoma (REAH) is a proliferation of well-differentiated glands lined by respiratory-type mucosa. The most frequent location is posterior part of nasal septum. It is considered to be a hamartoma, although some have suggested that it may be a neoplasm related to low-grade sinonasal adenocarcinoma.

This image is from a protruding polypoid mass removed from the left nares of a 48 y/o man. The polypoid fragment showed a proliferation of glandular spaces lined by ciliated epithelium, with a basal cell layer. The basal cells were p63 positive and SMA negative .

Image courtesy of: Nazim Benzerdjeb, MD, PhD, Pathology Department, Lyon University Hospital, Lyon, FRANCE; used with permission.

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