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Extranodal Rosai-Dorfman Disease : Retroperitoneum

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Extranodal Rosai-Dorfman disease that presented as large retroperitoneal mass in a young male. The image shows sheets of lesional histiocytes with foamy eosinophilic cytoplasm, and vesicular nuclei with punctate nucleoli. S-100 was strongly positive in the histiocytes. Aggregates of plasma cells are also present.

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