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Invasive Ductal CA : Tubule Formation

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The modified Scarff-Bloom Richardson grading system (Nottingham Combined Histologic Grade) is based on the degree of tubule/duct formation, nuclear grade, and mitotic rate.

Tubule/duct formation is a surrogate marker of the degree of glandular differentiation in invasive ductal carcinoma. It is assessed for the entire tumor at low magnification. Only the structures with clear-cut central lumina are counted. Scoring is done as follows: glands and tubules in >75% of the tumor (score 1), 10%-75% of tumor (score 2), and <10% of the tumor (score 3).

This case of high-grade invasive ductal carcinoma was composed mostly of solid areas, showed no evidence of tubule formation and was assigned score of 3 for tubule formation.

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