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Pleomorphic Adenoma

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The stroma of pleomorphic adenoma is synthesized by the myoepithelial cells and can have myxoid to chondromyxoid, fibrous or vascular appearance. This image depicts the chondromyxoid appearance of the stroma in a pleomorphic adenoma. The epithelial component shows tubular and acinar growth patterns. Grossly, the foci of cartilaginous differentiation appear translucent bluish-white. This feature is commonly seen in parotid and submandibular tumors. PA arising in minor salivary glands rarely show cartilaginous matrix production.

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