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Adult Granulosa Cell Tumor : Nested Pattern

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Architectural Patterns in Adult Granulosa Cell Tumor of the Ovary: In the insular (nested) pattern, the tumor cells are arranged in circumscribed nests and islands separated by variable amounts of fibroblastic, thecomatous, or hyalinized stroma.

The nested pattern with retraction artifact in this image has a striking resemblance to carcinoid tumor. However, at higher magnification, the presence of nuclear grooves and the absence of salt and pepper chromatin points to the correct diagnosis.

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