Striving to be the most comprehensive online resource for high-quality pathology images

 

Adenoid Cystic CA : Immunostains

prev  
slide 121 of 146
next
No Image
SalivaryGlands_ACC13_Immunos_MehmetSar_Resized.jpg

Close

Comments:
Adenoid cystic carcinoma (ACC) is composed of two cell typesabundant basaloid cells with myoepithelial differentiation and eosinophilic epithelial cells with ductal differentiation.

The ductal epithelial cells express cytokeratin (strongly), CEA, EMA, and CD117 (c-kit). Despite overexpression of the protein product, no c-kit mutations have been found and, not surprisingly, ACC does not respond to the tyrosine kinase inhibitor Imatinib (Gleevac) which has been successfully used to treat GIST and CML.

The basaloid cells around pseudocysts show myoepithelial differentiation and express p63, S-100 protein (patchy), actin (variable), vimentin, calponin and cytokeratin. Image courtesy of: Mehmet Sar, MD; Used with permission.

prev
slide 121 of 146
next