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Histiocytic Sarcoma : Treatment & Prognosis

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Treatment & Prognosis of Histiocytic Sarcoma: The prognosis is generally poor. In most cases, the disease pursues a relentless progressive course and patients die within a year of diagnosis. Larger tumor size and disseminated disease are associated with poor prognosis. Patients with clinically localized, resectable disease (a small group) have a somewhat more favorable outcome with survival periods ranging from 1 to 8 years. High-dose aggressive chemotherapy regimens used for acute leukemias sometimes work.

The image shows histiocytic sarcoma of small bowel that caused intestinal obstruction. The patient presented to the emergency room with severe abdominal pain, nausea and vomitting. There was history of fever and progessive weight loss. The intestinal architecture is distorted by sheets of pleomorphic tumor cells with abundant eosinophilic cytoplasm. There is an infiltrate of eosinophils, lymphocytes, and plasma cells in the background (images 10-15).

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