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Follicular Lymphoma : Growth Pattern

 
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Follicular lymphoma is a low-grade B-cell neoplasm composed of follicle center B-cells (centrocytes and centroblasts). It comprises approximately 40% of all adult non-Hodgkin lymphomas in the US. The most distinctive morphologic feature is nodular (follicular) pattern that attempts to recapitulate the architecture of a normal secondary lymphoid follicle.

This low-power scan shows a lymph node with follicular lymphoma. The nodal architecture is completely effaced with obliteration of subcapsular and medullary sinuses. The neoplastic follicles of varying sizes, with a homogenous appearance and lacking mantle zones and tingible-body macrophages, are evenly distributed throughout the lymph node. In contrast, the hyperplastic follicles in a reactive lymph node are mainly cortical in distribution.

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